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Article
May 2, 1966

Mixed Lymphocytes May Indicate Histocompatibility

JAMA. 1966;196(5):34. doi:10.1001/jama.1966.03100180020006

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Abstract

Thest formation in a mixed culture of lymphocytes from two individuals may have some value as an in vitro indicator of histocompatibility.

On the other hand, the activity of lymphocytes stimulated with phytohemagglutinin does not appear to be useful as an index of immunosuppression in patients after renal homotransplantation.

These were the preliminary findings of three investigators at the Medical College of Virginia, Richmond, who are attempting to evaluate two current hypotheses of potential significance to renal transplantation.

It has been suggested that, (1) the degree of stimulation of blast formation in a mixed culture of lymphocytes correlates inversely with the degree of histocompatibility between the two individuals, and (2) patients on immunosuppressive therapy have reduced blastogenesis, as compared to normals, both in mixed cultures and following stimulation with phytohemagglutinin.

To test the first proposal, James S. Wolf, MD, H. M. Lee, MD, and David Hume, MD, correlated activity of

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