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May 2, 1966


JAMA. 1966;196(5):448-449. doi:10.1001/jama.1966.03100180120043

Familial cardiomyopathy should be categorized as a member of the group of muscle diseases in which increases in serum enzyme activity may be found. This is the conclusion of Kariv and associates1 who recently reported the results of a study of a family in which six members of three generations had cardiomyopathy. The lactic dehydrogenase isozyme pattern observed in the sera of two of these patients was similar to the values found in several patients with myocardial infarction; these findings support the concept that the myocardium was the origin of the enzymes. Only the soluble sarcoplasmic glutamic oxaloacetic transaminase fraction was present in the serum, favoring the view that a change in cell membrane permeability rather than cellular destruction was responsible for the increased activity of serum enzymes.

The degree of increase of enzymatic activity could not be correlated with severity of clinical manifestations; the increases were greatest, for

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