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June 13, 1966


JAMA. 1966;196(11):1015-1016. doi:10.1001/jama.1966.03100240149040

Acute renal failure may be associated with the L hemoglobinemia which occurs in a number of clinical conditions. Can such failure appear, despite the absence of discoloration of urine to indicate the presence of a hemolytic state? How rapidly can functional impairment of the kidneys occur, and are the renal lesions reversible? The answers to these questions have awaited the establishment of an experimental model of clinical renal disease in the laboratory animal. An investigation utilizing such a model has been recently reported by Jaenike.1 Intravenous injections of hemoglobin in the rat produced acute renal failure and lesions which were relatively uniform in their manifestations. Serial inulin clearance measurements provided data on the functional evolution of the renal lesion from onset to virtual recovery. Histologic studies performed at each stage of the lesion by Jaenike and Schneeberger2 permitted correlation of the morphological changes with alterations in renal excretory

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