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June 20, 1966

Serum Glucose Concentrations

JAMA. 1966;196(12):1061. doi:10.1001/jama.1966.03100250071023

Glucose is the carbohydrate normally found in mammalian blood and is referred to as the "blood sugar." With few exceptions, it is equally distributed in the water of the extracellular fluids; as a result of the lower water content of the red blood cells, serum or plasma glucose values average 10% to 15% greater than those of whole blood. Because of variable results that accompany differences in hematocrit values in the multiphasic system of whole blood, and because plasma is the transport medium,1-2 it appears desirable to determine glucose levels in serum or plasma. The concentration is optimally quantitated by specific methods, preferably one of the enzymatic glucose oxidase procedures, rather than those that have come back in vogue with at least one of the automated techniques that determines total reducing substances.

Hypoglycemia and Hyperglycemia.—  Serum glucose concentrations represent the resultant of a balance between the rate of ingress

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