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July 11, 1966

Smokers' Blood Clots More Rapidly

JAMA. 1966;197(2):36. doi:10.1001/jama.1966.03110020022010

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Accelerated thrombus-like formation in blood taken from persons immediately after smoking has been observed in vitro by California investigators.

The hypercoagulable and hyperthrombotic state apparently induced lends credence to the theory that smoking contributes to the comparatively high incidence of acute myocardial infarction among heavy smokers, said Hyman Engelberg, MD, and Morton L. Futterman, MD, Los Angeles.

Blood flow within a rotating plastic (Chambers) loop is intended to approximate the process in vivo.

Their most recent study, confirmed earlier observations (JAMA193:1033-35, [Sept 20] 1965). Ninety-four males and 53 females were tested. These 147 smokers included 123 who favored cigarettes; 15, cigars; and nine, a pipe.

Blood samples were drawn just before the first cigarette of the day, at the end of the smoke, and 15 to 20 minutes afterward. Cigar and pipe users were sampled prior to and 15 to 30 minutes after "lighting up."

After citration and

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