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To the Editor:—
Conflicting opinions of the value of immune globulin in the prevention, amelioration, and cure of certain viral diseases are reported. The virus that causes verruca vulgaris, common as it is, must produce specific antibodies; hence the spontaneous regression. He who treats intractable warts is willing to grasp at almost any straw to relieve the poor patients who have widespread warts around the nail beds and on the soles of the feet. Seven such patients have been treated with immune globulin. In only one did the warts disappear promptly.In a disease that has spontaneous remission one cure in seven treated cases could not be statistically significant.
Johnson HA. Verruca Vulgaris Not Cured by Immune Globulin. JAMA. 1966;197(5):374. doi:10.1001/jama.1966.03110050112035
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