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August 15, 1966

Anti-γ-Globulin Factors in Visceral Larva Migrans

Author Affiliations

From the Bowman Gray School of Medicine, Winston-Salem, NC (Drs. Huntley and Watson, and Anne Lyerly); the University of Puerto Rico School of Medicine, San Juan, PR (Dr. Costas); and the University of Minnesota School of Medicine, Minneapolis (Dr. Williams).

JAMA. 1966;197(7):552-556. doi:10.1001/jama.1966.03110070076020

Sera from 26 of 59 children (1 to 5 years of age) with the visceral larva migrans syndrome were found to agglutinate γ-globulin-coated latex particles in titers of 1:16 to 1:4,096. The anti-γ-globulin factor was present during the acute phase of the disease and disappeared with clinical recovery in most patients. The factor was shown to be associated with the high molecular weight proteins by sucrose gradient centrifugation and Sephadex G 200 fractionation of sera. It is evident that young children do make antibodies which react with γ-globulin so that age alone cannot explain their relatively infrequent occurrence in juvenile rheumatoid disease.