Sera from 26 of 59 children (1 to 5 years of age) with the visceral larva migrans syndrome were found to agglutinate γ-globulin-coated latex particles in titers of 1:16 to 1:4,096. The anti-γ-globulin factor was present during the acute phase of the disease and disappeared with clinical recovery in most patients. The factor was shown to be associated with the high molecular weight proteins by sucrose gradient centrifugation and Sephadex G 200 fractionation of sera. It is evident that young children do make antibodies which react with γ-globulin so that age alone cannot explain their relatively infrequent occurrence in juvenile rheumatoid disease.
Huntley CC, Costas MC, Williams RC, Lyerly AD, Watson RG. Anti-γ-Globulin Factors in Visceral Larva Migrans. JAMA. 1966;197(7):552–556. doi:10.1001/jama.1966.03110070076020
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