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September 19, 1966

The Metabolic Basis of Inherited Disease

JAMA. 1966;197(12):1048-1049. doi:10.1001/jama.1966.03110120154052

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The second edition of this book follows the first by six years. The advances in genetics have been so extensive in this time that total revision has been necessary; not only has each chapter been rewritten due to advances within each subject, but several new chapters have been added. Some idea of this expansion may be gained from the fact that this edition weighs 7 lb compared to a little over 4 lb for the first. The quality of this edition, however, is also markedly improved. The book is divided into 12 parts and a short appendix. The introductory part has been expanded to three chapters covering basic principles of inherited variation and metabolic abnormality, coding, information transfer and protein synthesis, and the cytologie bases of human heredity. There is great emphasis on the newer knowledge of genetics in terms of regulatory processes expressed in current genetic nomenclature, eg, structural genes, operator genes,