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October 3, 1966


JAMA. 1966;198(1):77. doi:10.1001/jama.1966.03110140127037

Burkitt's lymphoma has attracted considerable interest in recent years due to its possible virus etiology. The antigenicity of the tumor is indicated by the total regression of the disease after chemotherapy in a considerable proportion of cases and by the absence of recurrences. Klein et al1 of Stockholm studied tumor-specific immunological reactions in lymphoma patients and assessed the significance of these reactions. Biopsy specimens were obtained from surgically excised Burkitt tumors in African patients. Indirect immunofluorescent antibody technique was used to demonstrate antigens in patients' sera. Serum donors were histologically confirmed lymphoma patients. Serum from control donors was procured from African inpatients with malignant disease, African inpatients with nonmalignant disease, and from healthy blood relatives of patients with Burkitt's lymphoma.

The observations suggested a tumor-specific antibody reaction to the specific lesion. Immunosensitive lymphomas were found to be more easily influenced by chemotherapeutic agents than were immunoresistant lymphomas. Also several