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October 17, 1966

Myocardosis and Cardiac Failure in Men

Author Affiliations

From the Creighton University School of Medicine, and the Omaha Veterans Administration Hospital.

JAMA. 1966;198(3):253-256. doi:10.1001/jama.1966.03110160081026

A disease entity, characterized by the subacute onset of severe myocardial failure was seen in 28 patients. Cardiomegaly, tachycardia, gallop rhythm, and findings of severe right-sided failure predominated. Typical electrocardiographic findings, marked elevation of the serum glutamic oxaloacetic acid and lactic dehydrogenase levels, and severe lactic acid acidosis were common. Eleven of the 28 patients died. Myocardial degeneration without fibrosis or inflammatory reaction was seen at autopsy. Extensive centrilobular necrosis of the liver was also present in the ten cases coming to autopsy. The etiology is uncertain. All of the patients ingested large amounts of beer over a long period of time. The recent description in Quebec of an entity with similar clinical findings and pathology, also occurring in a population ingesting large amounts of beer prompted this report.