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November 7, 1966

Host-Tumor Balance Factors Explored

JAMA. 1966;198(6):45-46. doi:10.1001/jama.1966.03110190023012

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[unk]t was less than 48 hours before the worldwide announcement that Charles Brenton Huggins, MD, would share the 1966 Nobel Prize in medicine.

As usual, Dr. Huggins was busy at the University of Chicago, where he has worked for almost 40 years.

But, instead of being in his shirt sleeves at the Ben May Laboratory for Cancer Research, which he heads, the just-turned-65-year-old physician was playing a key role in The International Symposium on Endogenous Factors Influencing Host-Tumor Balance.

Standing in the gleaming lobby of the University's nearly new Center for Continuing Education, where some 200 cancer researchers had gathered from the US and abroad, he summed up hormonal factors under discussion with three propositions:

  • Certain cancer cells differ utterly from the ancestral cells of their origin in fundamental response to hormone environment changes;

  • Removel of hormones can kill certain cancer cells which are hormone-dependent; and

  • Excessive