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November 14, 1966

Shigellosis in the Adult

JAMA. 1966;198(7):717-720. doi:10.1001/jama.1966.03110200073021

Within a four-year period 30 adults with shigellosis unrelated to any recognized epidemic were seen in a large city hospital. Shigella flexneri was responsible for two thirds of the cases and S sonnei for all but one of the remainder. A review of these cases demonstrated the diagnostic problems posed by sporadic disease. With the exception of dysentery, present in one half of the patients, no historical, clinical, or laboratory findings proved helpful diagnostically. One half of the patients received specific antibiotic therapy prior to clinical recovery. The course of the disease was similar in the treated and untreated groups. Antibiotic sensitivity studies performed on ten cultures revealed nine to be resistant to sulfonamides; resistance to antibiotics was unpredictable.