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November 21, 1966

New Fetal Blood Group Test

JAMA. 1966;198(8):42. doi:10.1001/jama.1966.03110210016005

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A fetal blood group detection technique that appears 30%-40% more accurate than any previous test has been developed by Dallas clinicians.

The procedure, which utilizes amniotic fluid, operates on the simple principle of mixed agglutination-inhibition familiar to blood bank technicians, L. Ruth Guy, PhD, said.

To date, the ABO blood group of 53 infants has been correctly predicted while they were in utero, she told the American Association of Blood Banks in Los Angeles. Only three incorrect forecasts, all early in the series, have resulted.

Dr. Guy is associate professor of pathology at the University of Texas Southwestern Medical School and associate director, Parkland Memorial Hospital Blood Bank. She developed the method in cooperation with Walter W. Taylor, MD, a Texas assistant professor of obstetrics and gynecology.

Virtually all cells, including those sloughed off by the fetus, contain ABO blood antigens, she explained. Previous methods have included agglutination tests on