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December 19, 1966

Ossification in Metastases From Carcinoma of the Breast

Author Affiliations

From the departments of radiation therapy and pathology, Columbus Hospital, Chicago.

JAMA. 1966;198(12):1309-1311. doi:10.1001/jama.1966.03110250123038

EXTRASKELETAL ossification has been frequently reported in soft tissues, especially after trauma and chronic inflammation. Rarely bone formation occurs in the primary sites of extraskeletal tumors. The organs most frequently undergoing such change are skin, breast, prostate, colon, and urinary bladder.1-5 In animals, especially female dogs, bone metaplasia in breast tumors occurs frequently.6 Heterotopic ossification in metastatic areas from carcinoma of rectum7,8 and urinary bladder9 has been previously reported. The purpose of this paper is to report a case of ossification in metastases from carcinoma of breast. To our knowledge, this is the first such case reported.

Report of a Case  A 61-year-old white woman was first seen at Columbus Hospital on Sept 27, 1956 for a painful mass of one year's duration in the left breast. On physical examination, a small tender tumor was felt in the inner lower quadrant of the left breast. The mass