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January 2, 1967


JAMA. 1967;199(1):A21-A32. doi:10.1001/jama.1967.03120010017004

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Quest For Safer Immunosuppression  Two apparently non-toxic techniques have substantially increased renal graft survivals in preliminary animal experiments by Miami investigators.Both laboratory systems seem "encouraging and provocative" leads in the search for safer immunosuppressive measures, Bernard S. Linn, MD, told JAMAMedical News.Investigations thus far have shown:

  • Prolonged pig-to-dog xenografts by suppression of a component of complement, and

  • enhanced dog-to-dog allograft survival using aminocaproic acid and prednisolone.

The cooperative studies involve clinicians and scientists at the University of Miami, Veterans Administration Hospital and the Howard Hughes Medical Institute.Too many kidney transplants survive rejection crises only to have the recipient succumb to bacterial infection. This is due to lowered resistance caused by such standard immunosuppressive agents as azathioprine (Imuran) or radiation.Much current work nationwide is concentrated on this prime barrier to transplantation's regular clinical use, noted Dr. Linn, associate chief of staff for research