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January 9, 1967

Hematologic Effects of Intrauterine Rubella

Author Affiliations

From the departments of pediatrics, Mount Sinai Hospital, Mount Sinai School of Medicine (Drs. Rausen and Tallal), City Hospital Center at Elmhurst (Dr. Rausen), New York University School of Medicine (Dr. Cooper), and the Department of Hematology, Mount Sinai Hospital, New York (Dr. Richter).

JAMA. 1967;199(2):75-78. doi:10.1001/jama.1967.03120020069011

Six of 21 newborn infants with congenital rubella studied in 1964 and 1965 had hematologic abnormalities. These six infants had transient thrombocytopenic purpura with sparse numbers of megakaryocytes in the bone marrow. In addition, they had indications of partially compensated hemolytic disease. These included abnormalities of red blood cell morphology, transient anemia at the end of the first month of life, and normoblastemia, reticulocytosis, and erythroid hyperplasia of the bone marrow in the immediate neonatal period. Other stigmata of intrauterine rubella in these six infants included congenital heart disease, cataracts, intrauterine growth retardation, hepatosplenomegaly, histologic evidence of hepatitis, metaphysitis of the long bones, hypospadias, and cryptorchidism.