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There was a great surge of interest in the apparent potentialities of bone marrow transplantation in the late 1950's, when it was discovered that to lethally irradiated animals marrow could be transplanted with life-saving effects. Many experimental and clinical studies followed. It soon became apparent that, with available techniques, the clinical potentialities of this procedure fell far short of what had been hoped for, and many investigators turned their efforts elsewhere. A number, including the author and his colleagues, have continued to study this intriguing area. He pauses at this time to examine the present state of the art. In so doing he presents an excellent, welldocumented review of pertinent animal studies, clinical trials, and technical methods.
Allogenic transplants in man (from an individual who is not an identical twin) have been tried in a number of diseases and under various conditions of irradiation or radiomimetic drug administration. The author
Best WR. Bone Marrow Transplantation. JAMA. 1967;199(2):138–139. doi:10.1001/jama.1967.03120020132046
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