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February 6, 1967

Relationship Between Stimulating Mechanisms of Gastric Secretion in Dogs

Author Affiliations

From the departments of surgery, Baylor University College of Medicine and Veterans Administration Hospital, Houston.

JAMA. 1967;199(6):399-405. doi:10.1001/jama.1967.03120060097017

Observations by Straaten1 and Unvas2 suggested that the cephalic phase of gastric secretion was dependent on a neurohumoral mechanism originating in the antrum. Thein and Schofield3 later provided critical evidence to support the concept that gastric secretion in response to vagal stimulation was partly due to vagal release of gastrin. Subsequently, it was demonstrated by Olbe4 and ourselves5 that antrectomy reduced the secretory response to cephalic stimulation by sham feeding.

Olbe6 further showed that administration of a subthreshold dose of gastrin restored to normal the sham feeding response reduced by antrectomy. That only a small amount of gastrin was required to permit full vagal response of parietal cells was suggested further by our work which estimated that vagally released gastrin approximated 16% of that released by direct chemical stimulation of the antrum.5

The present experiments were designed to study further potentiation of acid