It has long been suspected that psychic stress in man can be translated by the autonomic nervous system into a gastroduodenal environment favoring ulcerogenesis. The ulcerogenic potential of central autonomic lesions or stimulation, although presumptive in man, is well established in several species of laboratory animals.1
Marked alterations in gastric secretion and histology have been observed during central autonomic stimulation—changes which appear to depend on vagal innervation.2-6 The increased secretory response of denervated fundic pouches to acetylcholine lavage of the antrum has provided further evidence for the importance of the antral factor as a stimulant to gastric secretion during central autonomic stimulation (J. M. Pearl, MD, and A. S. Leonard, MD, PhD, unpublished data). The following experiments were undertaken to define the role of the peripheral vagus nerve and the antrum in the secretion of acid, pepsin, and mucus by the feline gastric mucosa during central autonomic nervous
Pearl JM, Lunseth JB, Ritchie WP, Gilsdorf RB, Leonard AS. Vagal and Antral Influences on Feline Gastric Secretion: Observations During Central Autonomic Stimulation. JAMA. 1967;199(6):406–410. doi:10.1001/jama.1967.03120060104018
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