THE NEW, broad-spectrum antiobiotic, gentamicin sulfate, is of particular interest in the treatment of eye infections. It is active against common staphylococci and streptococci,1,2Diplococcus pneumoniae, Haemophilus influenzae,3 and numerous species of gram-negative bacteria1-3 including Pseudomonas aeruginosa. In vivo, gentamicin protected rabbit eyes against destruction from experimentally induced pseudomonal infection.4 In one report of clinical use in eye infections,5 a few patients were treated successfully with gentamicin sulfate ophthalmic preparation for infection with Moraxella (diplobacillus of Morax-Axenfeld), Neisseria gonorrhoeae (gonococcus), and Haemophilus aegyptius (Koch-Weeks bacillus).
To study 0.3% gentamicin sulfate ophthalmic drops or ointment in eye infections, we treated 131 patients: 53 with the ointment, 72 with the drops, and 6 with both. Most (118) were treated for one week or less; 11 were treated for 8 to 13 days, and 2 for 20 to 30 days. Concurrent therapy included hot and cold compresses, atropine
Magnuson RH, Suie T. Gentamicin Sulfate in External Eye Infections. JAMA. 1967;199(6):427–428. doi:10.1001/jama.1967.03120060125030
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