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February 6, 1967

Mycoplasma Infections in Stevens-Johnson Syndrome

JAMA. 1967;199(6):435. doi:10.1001/jama.1967.03120060133039

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To the Editor:—  In a thorough review of Stevens-Johnson syndrome (198:113, 1966), D. B. Coursin discusses M pneumoniae as a possible etiologic agent for this syndrome. He states that Ludlam's report (Lancet1:958 [May 2] 1964) on serological studies on M pneumoniae infection in Stevens-Johnson syndrome needs further confirmation. We recently reported isolation of M pneumoniae in a patient with Stevens-Johnson syndrome (Lancet2:550 [Sept 3] 1966). Family members also had positive M pneumoniae cultures with respiratory ailments, following the same pattern we have seen in family studies of M pneumoniae (JAMA197:859, 1966). U. Reinhart also isolated M pneumoniae in a case of atypical pneumonia with erythema exudativum multiforme (Schweiz Med Wschr96:1027, 1966). These isolations of M pneumoniae can be considered confirmative evidence that this agent is involved in some cases of Stevens-Johnson syndrome.Further epidemiologic and laboratory studies will be required to