With use of a standard latex agglutination test, anti-γ-globulin factor was found in the serum of 16% of 325 elderly persons. There was no significant difference in the number of positive reactions between the sexes, but the percentage of seroreactors was higher among Jewish than non-Jewish women. Seventeen of the 52 seroreactors were found to have clinical evidence of rheumatoid arthritis. Antinuclear factor was found in 36% of 255 of these elderly persons. There was no correlation between positive antinuclear and anti-γ-globulin reactions. The concentrations of total serum protein and of serum albumin were slightly lower than those found in healthy young adults, while the concentration of serum γ-globulin was slightly greater.
Cammarata RJ, Rodnan GP, Fennell RH. Serum Anti-γ-Globulin and Antinuclear Factors in the Aged. JAMA. 1967;199(7):455–458. doi:10.1001/jama.1967.03120070067008
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