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February 13, 1967

Stevens-Johnson Syndrome: Report of a Case Associated With Culturally Proven Mycoplasma pneumoniae Infection

Author Affiliations


From the dermatology (Drs. Katz and Davis) and dental (Dr. Wooten) services, US Naval Hospital, and the Epidemiology Division, US Naval Medical Research Unit No. 4 (Dr. Griffin), Great Lakes, Ill. Dr. Katz is now with the University of Minnesota Hospital, Minneapolis.

JAMA. 1967;199(7):504-506. doi:10.1001/jama.1967.03120070116027

THE CLINICAL manifestations of Stevens-Johnson syndrome (erythema multiforme exudativum) were frequently observed in the dermatology and dental services at the US Naval Hospital, Great Lakes, Ill, during the late summer and fall of 1965. The apparently increased incidence of this syndrome prompted clinical as well as laboratory investigations. The serological evidence of associated Mycoplasma pneumoniae infection in Stevens-Johnson syndrome presented by Ludlam et al1 suggested Mycoplasma studies.

This communication is a case report of a patient with Stevens-Johnson syndrome in which an associated infection by M pneumoniae was documented by serological and cultural techniques.

Report of a Case  This 19-year-old white man was admitted to the US Naval Hospital, Great Lakes, on Oct 16, 1965, complaining of a widespread rash and sores in his mouth and on his penis.

History.—  He had been in a state of good health when he arrived at the Great Lakes Naval Station on