[Skip to Content]
[Skip to Content Landing]
February 27, 1967

Scanning for Tumors of Brain and Bone: Comparison of Sodium Pertechnetate Tc 99m and Ionic Strontium 87m

Author Affiliations

From the Division of Nuclear Medicine, Johns Hopkins Medical Institutions, Baltimore.

JAMA. 1967;199(9):610-614. doi:10.1001/jama.1967.03120090052009

Visualization by radioisotope scanning of areas of abnormal accumulation of radioactivity can be used to diagnose lesions such as brain tumors. The possibility that more precise diagnosis might be possible because of tissue specificity for different radiopharmaceuticals led us to compare the relative uptakes of radioactive pertechnetate and ionic strontium in brain and bone lesions. The results in experimental animals and man indicated that sodium pertechnetate Tc 99m was superior to strontium 87m for delineating brain tumors. Ionic strontium was more specific than pertechnetate in delineating bone tumors although pertechnetate also accumulated in such lesions. Because of the relative specificity of pertechnetate for delineating brain tumors and of ionic strontium for demonstrating bone tumors, the use of both nuclides was of value in the differential diagnosis of tumors in bone and brain. Their use was particularly helpful in distinguishing lesions of the skull from brain tumors.