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March 6, 1967

Nitrofurantoin Pneumonia

Author Affiliations

From the Division of Dermatology, Department of Medicine, University of California, San Francisco Medical Center, and the Ross (Calif) General Hospital.

JAMA. 1967;199(10):765-766. doi:10.1001/jama.1967.03120100127038

NITROFURANTOIN (Furadantin) is a well-tolerated antibiotic useful in a wide variety of urinary tract infections. In the last four years, eight patients have been reported with 22 bouts of pneumonia following use of nitrofurantoin.1-6 We have observed two additional patients, one with five bouts of pneumonia and one with one. This pneumonia is an unusual and peculiar one.

Report of a Case 

Case 1.—  The patient is a 46-year-old woman with recurrent urinary tract infections since age 10, having had almost annual recurrence of dysuria, frequency, backache, and fever. At age 35, cystoscopy showed urethral stenosis and scarring of the bladder; retrograde pyelogram was normal.At age 39 she was treated for 18 days with nitrofurantoin. After a week's interruption, treatment was resumed because of persistent symptoms. Within 24 hours of starting treatment with 100 mg four times a day, the temperature rose to 103 F (39.4 C) with