ARISING on all portions of the body, although most frequent upon the extremities, malignant soft-tissue tumors present different problems of total eradication dependent upon their exact anatomical site of origin, previous treatment, presence of metastases, and their histogenesis. Because these tumors are only infrequently radiosensitive and effective chemotherapeutic agents are not currently available, surgical removal continues to be the primary choice of treatment. Occult metastases may be present at the time the patient is first seen, particularly in the undifferentiated lesions. However, if all methods available for the detection of distant metastases are used, and no distant metastases are found, a well-conceived and executed operation may not cure, but should suffice for control of the primary tumor. Local persistence of the tumor following primary removal is an indication of poor planning or technical inadequacy, and the incidence of locally persistent disease is the best method of evaluating the adequacy
Eckert C. Surgical Treatment of Soft-Tissue Sarcomas. JAMA. 1963;184(1):65–67. doi:10.1001/jama.1963.73700140014023b
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