A phenomenon which cannot be explained by morphological studies only may be clarified by a biochemical approach to the problem. A fusion of information derived from both lines of investigation may reveal the role of vitamin C in the healing of wounds.
Vitamin C appears to be required for the formation of collagen precursors and collagen. Peacock1 has shown that development of adequate tensile strength in a healing wound can be independent of fibrogenesis. If vitamin C operates only through its effect on the production of fibrous tissue and if the tensile strength of a wound and the quantity of contained collagen are not intimately related, vitamin C would be of little or of no importance in the healing process. Catchpole2 found changes in plasma and connective tissue of scorbutic guinea pigs which suggested alteration in the chemistry of the ground substance, the continuous matrix which invests the
VITAMIN C AND HEALING OF WOUNDS. JAMA. 1963;184(4):307–308. doi:10.1001/jama.1963.03700170099016
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