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May 4, 1963

The Treatment of Angina Pectoris with Griseofulvin: Preliminary Communication

Author Affiliations

New Orleans

From the departments of medicine, Tulane University School of Medicine and Charity Hospital of Louisiana.

JAMA. 1963;184(5):421-422. doi:10.1001/jama.1963.73700180007016

BECAUSE of its fungistatic properties griseofulvin (Grisactin) is widely used in the treatment of many types of dermatomycoses in patients of all ages. Recently, an elderly patient with severe angina pectoris was noted to experience marked relief of his angina pectoris while receiving griseofulvin for the treatment of dermatomycosis. This finding was of sufficient interest to prompt us to evaluate the usefulness of griseofulvin in the treatment of other patients with angina pectoris. The beneficial results have been so striking as to justify this report.

Material and Methods  Griseofulvin in the form of micronized particles was administered to ten patients with angina pectoris and ischemic heart disease secondary to coronary arteriosclerosis. All of the patients were under the care of various physicians at the Charity Hospital Medical Clinic. They were receiving coronary vasodilators in the form of glyceryl trinitrate and one of the long-acting nitrate preparations. Diet and activity were