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The past century of medical progress has emphasized accurate description of clinical entities and their correlation with the underlying histopathological changes. This science, initiated 125 years ago by Virchow, provided the first real understanding of disease, its diagnosis, and its treatment. Much as the father of histopathology foresaw its extensions by other means, there was so much to be learned by means of the light microscope that the days seemed far away when disciplines such as chemistry, physics, and even mathematics would be integrated into the realities of medicine. They seemed completely remote to the understanding of disease, let alone to diagnosis or therapy.
The Second World War greatly increased the impact of science on man and his physical, mental, and political welfare. While the advent of the scientific and technological age brought new threats to the survival of the human race, public awareness of the implicit promise of longer
MEDICAL BIOLOGY. JAMA. 1963;184(6):496–497. doi:10.1001/jama.1963.03700190114019
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