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May 25, 1963


JAMA. 1963;184(8):35-54. doi:10.1001/jama.1963.03700210007003

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Chromosomal Disorders and Leukemias— An Etiological Relationship  Chromosomal abnormalities in patients with various congenital disorders and leukemias were reported by Dr. Jorge J. Yunis, director of the University of Minnesota Clinical Genetics Laboratory, before the American Association of Pathologists and Bacteriologists.Of 120 selected cases of suspected chromosomal defects studied during 1962, 25% had such abnormalities, Yunis said. Since 1959, when the first chromosomal abnormality was reported, several conditions have been shown to be associated with chromosomal defects, the researcher said. These conditions usually are manifested by a variation in the number or structure of chromosomes.It is now known, he said, that most cases of mongolism are due to nondisjunction, are sporadic and appear with increasing frequency in relation to the mother's age. A few cases, however, are of the hereditary type. These, usually found among young parents with mongoloid children, are due to the fact that one

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