Planned early delivery for selected, sensitized, Rh-negative patients to avoid fetal death or the delivery of severely anemic and hydropic infants resulted in the salvage of 59 of 73 Rh-positive infants. By previous and present experience maternal antibody titers have proved to be inadequate in predicting the severity of fetal involvement in utero. The selection of patients for early delivery was made primarily from obstetric history unless maternal hydramnios or cessation of fetal activity intervened. While this prognostic mechanism was adequate in most instances, there is obvious need for a means of accurately predicting the status of the individual fetus to prevent perinatal mortality from prematurity as well as from far-advanced hemolytic disease.
Goplerud CP. Preterm Delivery for Sensitized Rh-Negative Mothers. JAMA. 1963;184(8):626–630. doi:10.1001/jama.1963.03700210060010
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