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THE CHRONIC NATURE of diabetes insipidus necessitates an indefinite course of treatment. Hormonal substitution is obviously the preferred form of therapy. Nevertheless some patients cannot tolerate the natural vasopressor substance or, for other reasons are unable to receive intramuscular injections of the hormone for months or years. The alternative nasal vasopressin frequently injures the nasal mucosa and may cause a distressing rhinorrhea. To overcome these difficulties other methods of treatment have been suggested. Aminopyrine and members of the chlorthiazide group have been found advantageous for short term therapy but their use is limited. A more suitable substance would be a vasopressin, relatively free of side effects, which could be administered by means other than injection. Such a preparation, 8-lysine vasopressin nasal spray, proved effective in a patient with diabetes insipidus who experienced generalized allergic reactions to the natural hormone. His favorable clinical response to the 8-lysine vasopressin nasal spray, a
Spiegelman AR. Treatment of Diabetes Insipidus with Synthetic Vasopressin. JAMA. 1963;184(8):657–658. doi:10.1001/jama.1963.73700210020020a
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