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May 25, 1963

Hydrocortisone for Infection

Author Affiliations

Evanston, Ill.

JAMA. 1963;184(8):663. doi:10.1001/jama.1963.03700210097021

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To the Editor.  —The limitations in the Special Contribution, "The Effectiveness of Hydrocortisone in the Management of Severe Infections" (JAMA183:462 [Feb 9] 1963) are clearly apparent to the members of the cooperative study group, as is made evident by their remarks.The purpose of this letter is to draw specific attention to the fact that the analysis of detailed data and the section headed "Conclusions" deal only with adults. It is stated that a series of "children under 16" was studied, but apart from citing their low rate of mortality in the treated and placebo groups, the report concerns adults. The age grouping of the adults is given; the children are lumped together and simply referred to as being "under 16."It is not the purpose of this letter to comment about the use of hydrocortisone in the treatment of life-threatening infections but rather to call to mind

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