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Article
June 8, 1963

Council on Drugs

JAMA. 1963;184(10):772-773. doi:10.1001/jama.1963.03700230072013
Abstract

New Drugs and Developments in Therapeutics

The Colistins

COLISTIN is an antibiotic produced by the soil bacterium. Bacillus (Aerobacillus) colistinus (polymyxa var. colistinus). A polypeptide, composed of amino acids and a fatty acid, it is closely related chemically to polymyxin (NND 1963, pp 150-152). Colistin is also very similar to polymyxin B in its in vitro antibacterial range, which includes a number of gram-negative bacilli (Pseudomonas, Escherichia, Klebsiella, Aerobacter, Salmonella, Shigella, and Hemophilus), but not Proteus or gram-positive bacteria. Concentrations of colistin that are bactericidal in vitro are attainable in plasma and urine with clinical dosages and its antibacterial concentrations in vitro are comparable to those of polymyxin B. Plasma proteins exert little inhibitory effect on this in vitro antibacterial activity. Colistin has slight antifungal activity which may be of clinical benefit in discouraging the development of secondary moniliasis during therapy.

Colistin Sulfate and Colistimethate Sodium.  — Two compounds of

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