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June 15, 1963

References and Reviews

JAMA. 1963;184(11):902. doi:10.1001/jama.1963.03700240094023

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To the Editor:  —In the Reference and Review section of The Journal (183:201 [March 16] 1963), in a review of the paper by Bayley et al (J Clin Endocr22:1127 [Nov] 1962), the statement is made that estrogen treatment increases the rate of linear growth. This is contrary to my finding that the treatment arrests linear growth, as I have claimed in several earlier publications. The reviewer failed to note that Bayley et al did not follow the recommended treatment, ie, giving substantial doses of estrogen daily. Instead they administered the medication for only 20 days a month, leaving the adolescent girls 10 days time to rebound from the suppression of their pituitary function with acceleration of linear growth. Several other authors who have followed my recommendations of uninterrupted estrogen medication have found without exception that longitudinal growth can be arrested, thereby preventing these girls from attaining undesirable

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