THE DETECTION of antibody in humans infected by various species of malarial parasites has presented a problem for more than 50 years. Of all the tests, the complement-fixation reaction has provided the most information, but even with this test the chief difficulty has been the lack of a standardized specific antigen of sufficient sensitivity. During the course of complement-fixation studies of malaria, certain investigators have noted cross reactions. In 1927, Kingsbury1 reported that Plasmodium falciparum antigen reacted to about the same degree with P vivax antisera as with P falciparum antisera. However, the same amount of cross reaction did not occur when P vivax antigen was used. In this instance, the P vivax antigen detected the presence of antibody in 67% of the P vivax cases but in only 31% of the P falciparum cases. Some years later Eaton and Coggeshall,2 using antigen prepared from the parasite,
Tobie JE, Kuvin SF, Contacos PG, Coatney GR, Evans CB. Cross Reactions in Human and Simian Malaria. JAMA. 1963;184(12):945–947. doi:10.1001/jama.1963.73700250003012a
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