Four hundred eighty-two Negro tuberculous patients were followed after the admission sensitivity tests of their organisms to high levels of streptomycin, isoniazid, and para-aminosalicylic acid was known. They were classified on the basis of their histories as new or old patients, depending on whether or not they had had prior therapy; 44% of the new patients and 67% of the old patients had organisms resistant to one or more of the three antituberculous agents used. The patient's rate of recovery decreased as the resistance of his organisms increased. Patients with prior therapy developed chronic disease or died of their tuberculosis 3 1/2 times more frequently than patients without prior therapy.
Gerszten E, Brummer DL, Allison MJ, Hench ME. Increased Resistance of Mycobacterium Tuberculosis to Drug TherapyA Study of the Frequency of Drug-Resistant Tubercle Bacilli Among 482 Patients and Its Effect on Recovery. JAMA. 1963;185(1):6–10. doi:10.1001/jama.1963.03060010032004
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