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Article
July 20, 1963

Transplacental Transmission of Malignant Melanoma

Author Affiliations

Long Beach 6, Calif.

JAMA. 1963;185(3):221. doi:10.1001/jama.1963.03060030079045

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Abstract

To the Editor:—  An abstract under the title, "A Case of Transplacental Tumor Metastasis," (Acta Pediat52:123, 1963) appeared recently. A 9-week-old child, born of a mother who died 4 days post partum of metastatic malignant melanoma, was found to have several tumor masses, biopsy of one of which showed necrotic tissue containing melaninpositive pigment. X-ray examination of the chest revealed several thimble-sized, rounded, parenchymal lesions. The tumors and lung changes disappeared without therapy. It is difficult to determine from this report the exact nature of the lesions in this infant. There is also a recent publication on the experimental transmission of malignant melanoma cells through the placenta (Surg Gynec Obstet114:485, 1962). Diamandopoulos and Hertig in their article, "Transmission of Leukemia and Allied Diseases from Mother to Fetus," include the following reference: "A Case of Transplacental Metastasis of Malignant Melanoma from Mother to Fetus" (J Obstet Gynaec

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