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To the Editor:—
In an article in the March 2 issue of The Journal entitled "Effect of Glucagon Hydrochloride on Hypoglycemia of Juvenile Diabetics" (153:795), Dr. D. D. Etzwiler reports that subcutaneous injection of glucagon hydrochloride produced a rapid increase in blood sugar and a symptomatic improvement in juvenile diabetics experiencing severe hypoglycemic reactions.How does glucagon hydrochloride compare with epinephrine and posterior pituitary (Pituitrin) as an antagonist of insulin on blood sugar? A study was made, by this writer and associates, of epinephrine and posterior pituitary on the action of insulin on blood sugar. (Amer J Med Sci208:361, 1944.) In study of the effect of epinephrine on the action of insulin on glycemia, glucose tolerance tests were made of diabetics in three groups. Group 1 received 70 gm of dextrose only; group 2 received 70 gm of dextrose plus 20 units of unmodified insulin subcutaneously; and
Max Wishnofsky. Effect of Drugs on Glycemia. JAMA. 1963;185(4):328. doi:10.1001/jama.1963.03060040112043