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August 3, 1963

Urban Air Pollutants: Indicted as Carcinogenic Agents by Two NCI Investigators

JAMA. 1963;185(5):45. doi:10.1001/jama.1963.03060050021010

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While teams of investigators have been seeking a connection between cigaret smoking and lung cancer, other scientists (allergists, pathologists, etc.) have studied and indicted the urban air as an etiological factor in lung carcinoma.

Two such researchers, Dr. Paul Kotin and Hans L. Falk, PhD, both of the National Cancer Institute, presented a "constellation" of data that "strongly implicates the atmosphere as one dominant factor in the pathogenesis of lung cancer" at the annual meeting of the American College of Chest Physicians in Atlantic City.

In their paper, "Polluted Urban Air and Related Environmental Factors in the Pathogenesis of Pulmonary Cancer," they reported:

"Polluted urban air appears to be a reasonable explanation for the consistent observations of increased risk of urban residents to lung cancer, even after [mathematical] correction for smoking." Smoking habits, they added, account for "only a portion of the difference."

The identification and quantification of carcinogenic agents

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