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August 17, 1963

Delayed Audiofeedback (DAF) for Induction of Anxiety: Effect of Nortriptyline, Ethanol, or Nortriptyline-Ethanol Combinations on Performance with DAF

JAMA. 1963;185(7):556-558. doi:10.1001/jama.1963.03060070024017

By means of a delayed auditory feedback system, an anxiety situation was created in 16 subjects. Alcohol in low dosage (50 mg/100 cc blood level) effected a pronounced deficiency in performance. Nortriptyline did not alter performance, and when it was given in combination with ethanol the performance scores inclined to revert toward normalcy.