By means of a delayed auditory feedback system, an anxiety situation was created in 16 subjects. Alcohol in low dosage (50 mg/100 cc blood level) effected a pronounced deficiency in performance. Nortriptyline did not alter performance, and when it was given in combination with ethanol the performance scores inclined to revert toward normalcy.
Hughes FW, Forney RB. Delayed Audiofeedback (DAF) for Induction of Anxiety: Effect of Nortriptyline, Ethanol, or Nortriptyline-Ethanol Combinations on Performance with DAF. JAMA. 1963;185(7):556–558. doi:10.1001/jama.1963.03060070024017
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