Talipes equinus deformity of the foot, a common complication of hemophilia, often proves to be not amenable to correction by closed methods. It may be corrected by open operation, provided that postoperative hemorrhage is controlled by the use of lyophilized human fibrinogen rich in factor VIII. In the experience of the authors, illustrated by case histories, the preoperative use of this material is effective and safe. In non-resistant patients, infusion of fibrinogen resulted in predictable increases in the concentration of factor VIII in the plasma. Hepatitis and urticaria occurred in some cases.
Field RC, Enneking WF, Rothstein G. Elective Surgery in Hemophilia: I. Correction of Talipes Equinus Deformity. JAMA. 1963;185(8):628–630. doi:10.1001/jama.1963.03060080024007
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