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August 24, 1963

Craniopharyngeal Pituitary Gland

Author Affiliations

Kansas City, Kan.

From the Department of Pathology and Oncology (Dr. Nichols), and the Department of Medicine (Dr. Delp), University of Kansas Medical Center, Kansas City, Kan.

JAMA. 1963;185(8):643-646. doi:10.1001/jama.1963.03060080039011

A patient is described who did not mature and at age 20 had a calcified suprasellar cystic meningioma removed. For the next 24 years he showed all of the signs and symptoms of panhypopituitarism except normal pigmentation. At autopsy, a normal craniopharyngeal pituitary was found encased in bone and separated from the hypothalamus by a callus replacing the meningioma. Complete atrophy of thyroid and gonads indicated that thyrotrophic and gonadotrophic formation had ceased. Partial maintenance of adrenal cortices indicated a slight amount of ACTH was being formed, while normal pigmentation indicated melanotrophic hormone was still being formed in a normal amount.