Psoriasis is a disease of the skin which waxes and wanes, yields temporarily to many regimens, and is sometimes concentrated in families. The exact mode of inheritance has been a vexing matter. All of the monogenic mendelian models, and at least one two-gene model, have been proposed by one or another author, but each proposal has been contradicted later by someone else.
The latest genetic study is from the University of North Carolina, as reported in the July, 1963, issue of Archives of Dermatology (88:38). The authors were referred by a former student to a family of 815 persons spanning six generations and including 37 psoriatics. The opportunity to study psoriasis in a large homogeneous population under uniform conditions was used to assess several commonly held notions. It was shown by statistical tests that serum uric acid and cholesterol levels were not elevated in affected persons. Furthermore, the frequency
HEREDITY AND PSORIASIS. JAMA. 1963;185(8):660–661. doi:10.1001/jama.1963.03060080056016