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August 31, 1963

Partial Homograft Tolerance Can Be Attained: A human kidney, taken from a cadaver, has functioned for 16 months posttransplantation, according to a group of Boston physicians

JAMA. 1963;185(9):31-32. doi:10.1001/jama.1963.03060090009004

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What must be kept in mind, Dr. John P. Merrill of Peter Bent Brigham Hospital in Boston told The Journal, "is that tolerance to a human renal homograft is not an all-or-none phenomenon; partial tolerance can be attained and abortive rejection of the graft reversed with additional immunosuppressive therapy.

"At the present time there appear to be four empirical approaches to the conditioning of recipients for homotransplantation," he continued. "Total-body irradiation in so-called 'sublethal' doses... combinations of total-body irradiation and chemical suppression... focal irradiation to specific lymphoid tissue, including the spleen, the thymus, or the local recipient site... and drug therapy without the use of irradiation in any form. This last approach is the only one that has a consistent background of laboratory data."

He said that comparative experiences with these approaches will decide which techniques and combinations of drugs are best. He then summarized the experience of the Boston

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