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August 31, 1963

Adrenal Weight-Maintaining Corticotropin in Carcinoma of Lung

Author Affiliations

Kansas City, Kan.

From the Department of Pathology and Oncology, University of Kansas School of Medicine.

JAMA. 1963;185(9):696-698. doi:10.1001/jama.1963.03060090028010

In two cases of carcinoma of the lung without Cushing's syndrome but with bilateral adrenal cortical hypertrophy, the tumor was found to be devoid of corticotropin with corticosteroid-releasing capacity. Both tumors, however, had an extractable "corticotropin-like material" with adrenal weight-maintaining capacity. These findings, suggesting two different kinds of corticotropin, may explain the bilateral cortical hypertrophy not infrequently found in patients with tumors but without Cushing's syndrome.