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Article
Sept 7, 1963

An Undefined But Unique Autoregulatory Mechanism

JAMA. 1963;185(10):37-39. doi:10.1001/jama.1963.03060100013005

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Abstract

While the intestine, as a vascular area, appears to have its own autoregulatory mechanism, it differs in its oxygen consumption, blood flow, and vascular resistance from other organs of the body, said Dr. Paul C. Johnson, of the physiology department at Indiana University, where the symposium on autoregulation was held. He told the physicians that the "quiescent intestine" has a higher O2 consumption, and blood flow, but a lower vascular resistance than skeletal muscle. It has, on the other hand, a lower O2 consumption and blood flow than the brain or kidney.

In his studies, Johnson found that the O2 content of the venous flow from the intestine was "slightly higher" than that in skeletal muscle. "This might suggest," Johnson said, "a lower dependency upon metabolic factors." It has, in fact, been suggested, he added, that low venous O2 might be a "necessary requirement" for autoregulation.

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