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Sept 7, 1963

Reactive Hyperemia—Independent Of Blood Perfusion Pressure

JAMA. 1963;185(10):45-48. doi:10.1001/jama.1963.03060100021007

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"R eactive hyperemia is not dependent on the perfusion pressure within the system"... nor does the myogenic response to pressure "seem to be an important factor in reactive hyperemia." These were among the observations made by Dr. Lloyd R. Yonce of the Department of Physiology at the University of North Carolina, who related results of his experiments with pressure-flow relationships in isolated gracilis muscle to physicians at the Indiana University symposium on autoregulation.

Quoting a definition set forth in 1879, Yonce said, "Reactive hyperemia is the result of 'some stimulus acting directly on the walls of the vessel or indirectly on these through the medium of nutritive changes of the tissue elements.' " More recent concepts, he added, "are no more than specific restatements of this idea." He in turn called reactive hyperemia "the manifestation of the vasodilatation or loss of tone during the period of circulatory arrest," and he offered

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