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Dr. Ellis is quite right in commenting that radiation therapy in Hodgkin's disease holds a prominent place. It is the most effective form of treatment, usually, for localized manifestations of both Hodgkin's disease and lymphosarcoma.
In our experience, however, pleural effusion due to almost all types of neoplastic disease, including Hodgkin's, is best treated by the method described. The intracavitary administration of nonvesicant oncolytic drugs as thio-tepa and cyclophosphamide (Cytoxan) is simple, highly effective, and unassociated with subsequent undesirable fibrosis.
Bateman JC. Pleural Effusion in Hodgkin's Disease-Reply. JAMA. 1963;185(10):808. doi:https://doi.org/10.1001/jama.1963.03060100087032
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