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Sept 14, 1963

The Humoral Nature Of Homograft Rejection

JAMA. 1963;185(11):24-26. doi:10.1001/jama.1963.03060110004003

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"Since Medawar and McFarlane Burnet first observed that homograft immunity—or the rejection of a homograft—was the result of the migration of cells from the reticuloendothelial system into the graft with subsequent destruction of the graft by these cells, there has accumulated enough evidence to make us believe that the rejection of the homograft is humoral," Dr. Richard J. Bing, of Detroit, Mich., told The Journal.

He described recent experiments investigating the mechanism of rejection in dogs with transplanted hearts which are being conducted at Wayne State University College of Medicine and Harper Hospital in Detroit. Dr. Chiyo Chiba performs the surgery during these experiments.

The heart was used, Bing explained, "because transplantation of this organ is easy to carry out; its immunological response can be rapidly judged by changes in metabolism; and finally, the period between transplantation and rejection is brief since vascular connections are rapidly established and changes in

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